The regenerative capacity of organs and tissues decreases with age. First signs of diminished resilience of elderly as compared to young individuals are observed as early as at the age of 45 to 50 after traumatic injuries. Besides several other factors, cellular senescence has been identified as a key driver of aging, age-associated diseases. We aim to understand understand how senescent cells impact organ and tissue function and regeneration and find ways to modulate their influence.
Johannes Grillari (Ludwig Boltzmann Institute for Traumatology, the research center in cooperation with AUVA, University of Natural Resources and Life Sciences Vienna)
Heinz Redl & Mikolaj Ogrodnik (LBG Research Group: Senescence and Healing of Wounds)
Florian Gruber (Medical University of Vienna)